Excipients are essential ingredients of almost any dermatological product and required to assure numerous properties of the final preparation, such as spreadability, solubility and stability. Perspectives about the safety and tolerance of ingredients in dermatology have changed due to advanced research and increasing numbers of adverse reports [1].
Examples of frequently used harmful excipients are propylene glycol and sodium lauryl sulfate. Propylene glycol is commonly used to solubilise drugs in topical preparations. However, it can induce contact dermatitis and is known for irritating the skin, especially in children [1,2]. Sodium lauryl sulfate, a surfactant widely used in dermatological preparations, disrupts the skin barrier in healthy volunteers and can cause irritation, erythema and dehydration of the skin [3]. Since most dermatological preparations are used on the vulnerable skin, it is even more essential to minimise the risk for adverse reactions.
Fagron Advanced Derma offers a range of skin friendly vehicles for different skin types and applications. The vehicles do not cause skin irritation or long-term adverse or allergic reactions and are uniquely suited for use on sensitive and vulnerable skin. The careful selection of ingredients has resulted in vehicles that can be used by all patient groups.
References:
[1] American Academy of Pediatrics, Committee on Drugs. Inactive ingredients in pharmaceutical products: update (subject review). Pediatrics. 1997;99(2):268–278.
[2] Yoo JY, et al. Allergic contact dermatitis: patch testing results at Mount Sinai Medical Center. Skinmed. 2010;8(5):257-60.
[3] Törmä H et al. Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo. J Invest Dermatol. 2008;128(5):1212-9.
